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However, Glp1r/ mice treated with the GLP-1/Gcg coagonist experienced a reduction in body weight and fat mass but did not have improvements in glucose tolerance indicating that GLP-1R agonism is required to counteract the hyperglycemic effects of GcgR agonism (Day et al., 2013)

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doi: 10.1016/j.brainres.2015.11.024 94

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Although short-term studies ( 3 months) often show minimal changes in HbA1c, sustained improvements in insulin sensitivity over time are expected to translate into better glycemic control and improved long-term cardiometabolic outcomes [50, 51]