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Of note, the mean basal insulin dose at the study endpoint (week 52) was 48.8 U with insulin degludec in the SURPASS-3 trial and 43.5 U with insulin glargine in the SURPASS-4 trial [20, 21]

3e), suggesting that cyclic fasting as an additional nutritional stressor is necessary to trigger p53-controlled macrophage accrual

However, rigorous controlled head-to-head solo-vs-combined trials remain rare, and most stacking claims rest on mechanistic plausibility plus individual-compound efficacy data

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