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Some preliminary studies suggest allulose might interact with sweet taste receptors (T1R2/T1R3) or other nutrient-sensing mechanisms on enteroendocrine cells

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Physiological oral mucosal melanin hyperpigmentation is very common in Blacks, in general is more frequent in darker-skinned than in lighter-skinned persons regardless of their race/ethnicity, and is most probably caused by genetically determined metabolic hyperactivity of oral melanocytes