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From a public health standpoint, the impact of TMAO elevation during l-carnitine supplementation is unknown, but both vegan/vegetarian and omnivore on average showed a greater than 10-M increase in circulating TMAO levels with l-carnitine supplementation

This elevation is not limited to healthy populations

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Association of weight loss interventions with changes in biomarkers of nonalcoholic fatty liver disease: a systematic review and meta-analysis