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Acta Paediatr Jpn 40:2629 van Es A, Henny FC, Kooistra MP et al (1992) Amelioration of cardiac function by L-carnitine administration in patients on haemodialysis

The EC50 of GLP1 (7-36) is in the expected 2 digits pM range (25-60pM), while its metabolite shows a potency which is 4 logs lower and falls into the low M range

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This is a normal physiological response to caloric deficit and increased fat metabolism