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Women of childbearing age must use reliable contraception while on GLP-1 therapy, and treatment should be discontinued at least 2 months before attempting pregnancy to ensure complete drug clearance

While there have been isolated reports of mood changes or depressive symptoms in some individuals, these cases are rare and often involve patients with pre-existing psychiatric conditions. So far, the existing studies dont find a significant increase in psychiatric adverse events compared to placebo

Melanoma cells are characterized by the disruption of cell-cell adhesion molecules between melanocytes and keratinocytes

He added that his surprise doesnt stem from any concerns over the mechanism of action for the two drugs, but rather because orforglipron has not gone through the extensive evaluation of adverse effects since its not approved yet

Pillai, S

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