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In many cases where MTHFR is mild, oral glutathione supplementation alone is sufficient to effect dramatic improvement

10.1186/s13020-022-00677-6 70 WarnakulasuriyaS.ChenT

Biomarkers are important in confirming AD pathology and guiding targeted therapies 6

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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)