Percentage Change in Body Weight The mean on-treatment change in body weight was 5.9% (95% CI, 6.0% to 5.8%) for tirzepatide vs 3.6% (95% CI, 3.7% to 3.4%) for semaglutide at 3 months, 10.1% (95% CI, 10.4% to 9.9%) vs 5.8% (95% CI, 6.0% to 5.5%) at 6 months, and 15.3% (95% CI, 16.0% to 14.5%) vs 8.3% (95% CI, 9% to 7.6%) at 12 months (Figure 4)
Diarrhea Replace the fluid youre losing
However, the absence of documented cases does not definitively exclude the possibility of an association, particularly given the relatively recent widespread use of semaglutide
The dosage may be increased to up to 2mg per week if additional glycemic control is needed
Significant weight loss is typically observable by this point
These side effects are typically transient and diminish as the body adjusts to the peptide during the initial 4-week phase