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By inhibiting PP6-mediated dephosphorylation, this degradation activates focal adhesion kinase (FAK) and MOB1, reducing focal adhesion density and size while enhancing migratory capacity ( In summary, small GTPasesparticularly the Rab40 familyfunction as substrate receptors that assemble with CUL5 to form ubiquitin ligase complexes, thereby regulating cell migration through ubiquitination and degradation of diverse substrate proteins

Song YJ, Zhong CB, Wang XB (2018) Heat shock protein 70: a promising therapeutic target for myocardial ischemiareperfusion injury

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Accumulation of toxins in the body and increased oxidative stress, which also leads to premature aging