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Furthermore, studies using cell lines and mouse models harboring genetic mutations linked to familial AD, have demonstrated that a compromised mitochondrial antioxidant defense, unable to handle mitochondrial-derived ROS, promotes the amyloidogenic pathway and the activity of MAPT/TAU-related kinases, thus contributing to establish a vicious cycle of oxidative stress and damage [44,98,99]

2014), the FAK-paxillin pathway (Chang et al

recently showed that direct GPx4 overexpression in the cellular models (A549, H460 and H1299 and H23) of non-small cell lung carcinoma (NSCLC) prevented the radiation-induced lipid peroxidation and, in turn, contributed to radioresistance by blocking the ferroptosis mode of cell death [56]

Skin lightening treatments inhibit melanin production, the pigment responsible for our skin and eye colour