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They should mainly be used as second-line therapy as add on to metformin in patients with type 2 diabetes who have no pre-existing cardiovascular disease and have a therapeutic goal to avoid hypoglycaemic events
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However, this typically requires ongoing treatment to maintain
Most data comes from animal studies, so long-term safety and rare side effects remain unclear
Examination of the cysteine-rich leucine-rich repeat (LRR) domain of NLRP3 reveals a molecular mechanism by which redox status can regulate its activity
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