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For example, astrocyte-neuron metabolic shuttles, such as the glutamateglutamine cycle, are affected by mitochondrial inefficiency and oxidative stress, reducing synaptic plasticity and impairing glymphatic clearance during sleep (Vyazovskiy and Harris, 2013

These medications should be used under medical supervision as part of a comprehensive weight management program

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That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them

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The TFs involved in the reaction to HM stress and tolerance have been reported in several plant species (Niekerk et al., 2024)