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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

Do you feel exhausted and worn out for as long as you can remember but also struggle to rest or get off to sleep as your mind just won't slow down

Chang, C.-H., Tsai, W.-C., Lin, M.-S., Hsu, Y.-H., & Pang, J.-H

Nature Communications (2016) 11

including adult patients with either T1D or T2D treating with mecasermin rinfabate (12 mg/kg/day for 14 days) showed lowered exogenous insulin requirements while improving glycaemic control

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