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Compared to the control serum, GHK-Cu reduced wrinkle volume by 55.8% and wrinkle depth by 32.8%

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Interestingly, global IGF-I KO, Cart IGF-IR / , and TamCar IGF-IR / mice all show increased expression of PTHrP protein and RNA, but decreased Ihh expression in their growth plates, indicating a disrupted PTHrP/Ihh feedback loop (26,32)

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Continuous multi-month use is widely discouraged