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The PIN7 groups treated with lysozyme and heat-killed variants demonstrated elevated colonic expressions of toll-like receptors and epithelial junction proteins, along with reduced expressions of pro-inflammatory mediators, p-IB and mucosal injury scores in the colons of colitis mice [153]

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KPV has strong mechanistic evidence from published research in Gastroenterology and other peer-reviewed journals, with well-characterized pathways (NF-kB inhibition, PepT1 transport) and positive results in established animal models of colitis