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However, they must be prescribed by a qualified doctor after a thorough medical evaluation

Weight Loss: How Off-Label Use Increased Ozempic Injuries While the FDA approved Ozempic specifically for Type 2 diabetes management to help control blood sugar, the drugs ability to cause significant weight loss led to widespread off-label prescribing for chronic weight management

Detailed information on each dataset is provided in Table S1 [26]

Currently, there is only one drug in this class of medicationstirzepatide, which is approved as Mounjaro for treatment of Type 2 diabetes and as Zepbound for the treatment of obesity

Key exclusion criteria included: diagnosis of type 1 or type 2 diabetes, use of approved weight-lowering pharmacotherapy within the previous 3 months, previous anti-obesity surgery, cardiovascular diseases and thyroid stimulating hormone outside reference range

Three physiological GPX4 isoforms, including cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), have been identified