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T.SenisterraG.HuntleyS.LepockJ

The PerR transcription factor is triggered not by oxidation of a sensory thiol but by the oxidation of a prosthetic iron atom, in a Fenton-type reactionan event that seems likely to be H 2 O 2 -specific ( 2 O 2 defenses like AhpCF and catalase and the miniferritin Dps, but they do not usually include thioredoxins and glutaredoxins ( Streptomyces coelicolor and the Spx systems of Bacillus subtilis and Staphylococcus aureus have been most closely studied ( 2 O 2 is not an effective trigger for these regulons, and the natural inducers remain unknown

Autophagy 12 (8), 14251428

During the course of EAE and in MS patients, increased iron content was reported in microglia/macrophages at lesion sites (63, 67)

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It also reduces the amount of somatostatin, a GH-inhibiting hormone