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SW480 cells treated 5FU for 72 h analysed for mitochondrial mass by NAO staining ( a ) and mtDNA ( b ), n = 3 biological replicates shown with mean s.e.m in both, and mitochondrial protein expression ( c ), blots representative of n = 3 biological replicates

Similar observations were noted in later human studies [56, 57], with the peak serum TMAO observed within hours following oral administration of the tracer [56]

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"Hidden pharmacological activities of valproic acid: A new insight"

If you prefer injecting IM, follow the same instructions

Therefore, caution should be exercised regarding co-administration of iron chelators which may antagonize the anti-leukemic activity of APR-246, as we observed in vitro