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Historical Background and Scientific Context Scientific interest in synthetic peptide complexes has expanded significantly with advances in molecular biology and biochemical research

However, their clinical translation is often impeded by inherent challenges such as poor bioavailability, limited aqueous solubility, and rapid systemic clearance, which collectively hinder their effective delivery to targeted ocular tissues [347]

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Full trial data: Lincoff et al., NEJM, 2023

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Hence, one of the questions that remains to be clearly answered is whether the reported GSH decrease in IBD is an epiphenomenon of colitis or if GSH depletion plays any pathophysiological role in the development of colitis