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The STEP clinical trials tested weekly semaglutide doses of 0.5 mg, 1.0 mg, and 2.4 mg over 68 weeks, showing that 2.4 mg produced the greatest average weight loss (approximately 18% of baseline body weight), though 1.0 mg and 1.7 mg often deliver sufficient results with fewer side effects for many patients

Some of these control mice were put on a diet so that they lost weight at the same rate as the mice using semaglutide

Emerging competitors are advancing differentiated mechanisms beyond single GLP-1 agonism

A6 : Intended for adults

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