There is a relatively high discontinuation rate due to gastrointestinal side effects
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Apart from formulation techniques, the composition of gut microbiota affects the metabolism of resveratrol
Side effects, which vary by drug, include myopathy and peripheral neuropathy (telbivudine), kidney toxicity and dysfunction (tenofovir and adefovir), decreased bone mineral density (tenofovir), and lactic acidosis in patients with liver disease (entecavir) (Scaglione 2012)
Food and Chemical Toxicology, 128, 129136