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Randomized Trial Data on Weight Loss Outcomes STEP-1: Semaglutide 2.4 mg The STEP-1 trial enrolled 1,961 adults with a BMI of 30 or higher (or 27 with at least one weight-related comorbidity) and no type 2 diabetes

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Safety and Side Effect Management During Dose Changes Nausea, vomiting, and appetite loss are the most common side effects during semaglutide dose escalation, typically subsiding within 3 to 7 days as your body adapts