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Brain tissue homogenates and serum samples were collected to quantify intestinal permeability markers (zonulin and occluding), oxidative-stress markers (GSH, MDA, CAT), and GABA-receptor gene expression using ELISA and biochemical assays

[DOI] [PubMed] [Google Scholar] 56.Marazuela M., Garca-Lpez M.A., Figueroa-Vega N., de la Fuente H., Alvarado-Snchez B., Monsivis-Urenda A., Snchez-Madrid F., Gonzlez-Amaro R

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The changes were correlated with day 1 changes in clinical and anhedonia scales (MADRS, QIDSSR, M3VAS, SHAPS, TEPS-A and TEPS-C)

Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks

Indication breadth keeps growing Zepbound is now FDA-approved for obstructive sleep apnea in adults with obesity, and additional indications (NASH/MASH, kidney disease, addiction-adjacent endpoints) are under investigation