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A stressed state shunts blood away from the digestive system, whereas a relaxed state is optimal for digestion, and can help with constipation

Timing of administration may influence interaction dynamics

DF, JB, and AS contributed the reagents, materials, and analysis tools

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Thanks to this, it can be taken at any time, regardless of meals or time of day, making it easier for patients to adhere to the regimen

Kidney Dysfunction: While the kidneys do not directly excrete vitamin B12 efficiently, impaired renal function may lead to elevated serum B12 levels by reducing the clearance of B12-binding proteins or altering their metabolism, thereby contributing to B12 accumulation 8