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One of the earliest clinical trials of electronic cigarettes was conducted at the University of Auckland, New Zealand

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In an experimental mouse model, exposure to cigarette aerosols during the early life stage (detected through urine cotinine levels) altered frontal cortex development 40

Furthermore, the previous TSCE model was essential when the CISNET Lung Working Group conducted decision analyses, which provided supporting evidence in updating the United States Preventive Services Task Force (USPSTF) lung cancer screening recommendations [57]

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