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The new study, Handa says, shows smoking also causes epigenetic changesnon-permanent shifts in gene expression that are not caused by changes in a cell's DNA sequenceto retinal pigmented epithelial cells, or RPE cells, that have widespread effects on the eye and its ability to respond to environmental stress

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A meta-analysis of maternal smoking during pregnancy and autism spectrum disorder risk in offspring

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Moderation, in this case, is most definitely a vice from a health perspective, and a potentially life-shortening approach.