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Regarding terminology, nicotine dependence is described by the World Health Organization (WHO) as a disorder of regulation of nicotine use arising from repeated or continuous use .(1) Tobacco use disorder is the relevant term described by the American Psychiatric Association in their Diagnostic and Statistical Manual of Mental Disorders.(2) Withdrawal symptoms are another concern for about half of smokers when they initially quit smoking, including difficulty concentrating, anxiety, and dysphoria (meaning distress or discomfort with life).(3) While quitting smoking can be difficult, it is very much possible, and millions of smokers quit every year

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PLoS ONE 10 , e0129296 (2015)