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Key considerations include the FDA's Premarket Tobacco Product Application (PMTA) process in the US, the EU's Tobacco Products Directive (TPD) requirements (e.g., tank capacity limits, nicotine concentration caps, notification processes), and country-specific regulations concerning flavors, nicotine strengths, packaging, and marketing restrictions

Source: CDC It is terrific news for our nations health that the adult cigarette smoking rate fell to a record-low 14 percent in 2017, down from 15.5 percent in 2016 and a remarkable decline of 67 percent since 1965 (when 42.4 percent smoked)