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The ME mucosa transforms from a monolayer of simple squamous epithelium to a full-thickness pseudostratified columnar respiratory epithelium containing secretory and ciliated cells within a few days of developing OM, as seen in both animal models and humans 4,5,6,7,8,9

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Endogenous mRNA is eliminated while ribosomal integrity is maintained, resulting in a robust lysate that efficiently translates added templates