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According to the FDA, most healthy adults can safely consume up to 400 milligrams (mg) of caffeine daily, which is equivalent to about four cups of coffee, ten cans of cola, or two energy shots

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Ethics declarations Ethics approval and consent to participate This study was reviewed and approved by the Ethics Committee of Jilin University School of Public Health (No.2015-12-08), and written informed consent was obtained from all subjects before they participated in the study