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For prostate cancer, CVDs and all the other outcomes except for fractures, we used cigarette-equivalents smoked per day as the exposure for current smoking, because smoking intensity is generally thought to be more important than duration for these outcomes

Importantly, EC-induced oral dysbiosis disrupts microbial homeostasis, fostering pathogenic proliferation and metabolic alterations that contribute to a spectrum of oral pathologies, including periodontitis and oral carcinogenesis