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Their conclusion is blunt

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Whereas we operationalized chronic effects as structural alterations identified in smoker versus nonsmoker (i.e., between-subjects) comparisons, we operationalized the acute effects of nicotinic acetylcholine receptor (nAChR) agonist administration as functional alterations indentified in pharmacological neuroimaging studies, the vast majority of which employed within-subjects (i.e., drug versus control condition) comparisons

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